The effect of an adverse psychological environment on salivary cortisol levels in the elderly differs by 5-HTTLPR genotype
Identifieur interne : 000219 ( Main/Exploration ); précédent : 000218; suivant : 000220The effect of an adverse psychological environment on salivary cortisol levels in the elderly differs by 5-HTTLPR genotype
Auteurs : Marie-Laure Ancelin [France] ; Jacqueline Scali [France] ; Joanna Norton [France] ; Karen Ritchie [France, Royaume-Uni] ; Anne-Marie Dupuy [France] ; Isabelle Chaudieu [France] ; Joanne Ryan [France, Australie]Source :
- Neurobiology of Stress [ 2352-2895 ] ; 2017.
Abstract
An adverse psychological environment (e.g. stressful events or depression) has been shown to influence basal cortisol levels and cortisol response to stress. This differs depending on the adverse stimuli, but also varies across individuals and may be influenced by genetic predisposition. An insertion/deletion polymorphism in the serotonin transporter gene (
To investigate how stressful life events and depression are associated with diurnal cortisol levels in community-dwelling elderly and determine whether this varies according to genetic variability in the
This population-based study included 334 subjects aged 65 and older (mean (SD) = 76.5 (6.3)). Diurnal cortisol was measured on two separate days, under quiet (basal) and stressful conditions. The number of recent major stressful events experienced during the past year was assessed from a 12-item validated questionnaire as an index of cumulative recent stressful events. Lifetime trauma was evaluated using the validated Watson's PTSD inventory, which evaluates the most severe traumatic or frightening experience according to DSM criteria. Depression was defined as having a Mini-International Neuropsychiatric Interview (MINI) diagnosis of current major depressive disorder or high levels of depressive symptoms (Center for Epidemiologic Studies-Depression Scale ≥16).
Exposure to stressful life events was associated with lower basal evening cortisol levels overall, and in the participants with the
An adverse psychological environment is associated with basal cortisol levels and cortisol stress response, but this differs according to
Url:
DOI: 10.1016/j.ynstr.2017.03.002
PubMed: 28377990
PubMed Central: 5369865
Affiliations:
- Australie, France, Royaume-Uni
- Languedoc-Roussillon, Occitanie (région administrative), Victoria (État), Écosse
- Melbourne, Montpellier, Édimbourg
- Université d'Édimbourg, Université de Melbourne
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first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><affiliation wicri:level="3"><nlm:aff id="aff1">Inserm, U1061, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">University of Montpellier, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Scali, Jacqueline" sort="Scali, Jacqueline" uniqKey="Scali J" first="Jacqueline" last="Scali">Jacqueline Scali</name><affiliation wicri:level="3"><nlm:aff id="aff1">Inserm, U1061, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">University of Montpellier, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Norton, Joanna" sort="Norton, Joanna" uniqKey="Norton J" first="Joanna" last="Norton">Joanna Norton</name><affiliation wicri:level="3"><nlm:aff id="aff1">Inserm, U1061, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">University of Montpellier, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="3"><nlm:aff id="aff1">Inserm, U1061, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">University of Montpellier, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Center for Clinical Brain Sciences, University of Edinburgh, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Clinical Brain Sciences, University of Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Dupuy, Anne Marie" sort="Dupuy, Anne Marie" uniqKey="Dupuy A" first="Anne-Marie" last="Dupuy">Anne-Marie Dupuy</name><affiliation wicri:level="3"><nlm:aff id="aff1">Inserm, U1061, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">University of Montpellier, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4">Lapeyronie University Hospital, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Lapeyronie University Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Chaudieu, Isabelle" sort="Chaudieu, Isabelle" uniqKey="Chaudieu I" first="Isabelle" last="Chaudieu">Isabelle Chaudieu</name><affiliation wicri:level="3"><nlm:aff id="aff1">Inserm, U1061, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">University of Montpellier, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><affiliation wicri:level="3"><nlm:aff id="aff1">Inserm, U1061, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">University of Montpellier, Montpellier, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff5">Disease Epigenetics Group, Murdoch Children's Research Institute and Department of Paediatrics, The University of Melbourne, Parkville, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Disease Epigenetics Group, Murdoch Children's Research Institute and Department of Paediatrics, The University of Melbourne, Parkville</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Department of Epidemiology and Preventative Medicine, School of Public Health and Preventative Medicine, Monash University, Prahran, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Epidemiology and Preventative Medicine, School of Public Health and Preventative Medicine, Monash University, Prahran</wicri:regionArea><wicri:noRegion>Prahran</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neurobiology of Stress</title><idno type="eISSN">2352-2895</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>An adverse psychological environment (e.g. stressful events or depression) has been shown to influence basal cortisol levels and cortisol response to stress. This differs depending on the adverse stimuli, but also varies across individuals and may be influenced by genetic predisposition. An insertion/deletion polymorphism in the serotonin transporter gene (<italic>5-HTTLPR</italic>) is a strong candidate in this regard.</p></sec><sec><title>Objective</title><p>To investigate how stressful life events and depression are associated with diurnal cortisol levels in community-dwelling elderly and determine whether this varies according to genetic variability in the <italic>5-HTTLPR</italic>.</p></sec><sec><title>Methods</title><p>This population-based study included 334 subjects aged 65 and older (mean (SD) = 76.5 (6.3)). Diurnal cortisol was measured on two separate days, under quiet (basal) and stressful conditions. The number of recent major stressful events experienced during the past year was assessed from a 12-item validated questionnaire as an index of cumulative recent stressful events. Lifetime trauma was evaluated using the validated Watson's PTSD inventory, which evaluates the most severe traumatic or frightening experience according to DSM criteria. Depression was defined as having a Mini-International Neuropsychiatric Interview (MINI) diagnosis of current major depressive disorder or high levels of depressive symptoms (Center for Epidemiologic Studies-Depression Scale ≥16). <italic>5-HTTLPR</italic> genotyping was performed on blood samples.</p></sec><sec><title>Results</title><p>Exposure to stressful life events was associated with lower basal evening cortisol levels overall, and in the participants with the <italic>5-HTTLPR L</italic> allele but not the <italic>SS</italic> genotype. The greatest effects (over 50% decrease, p < 0.001) were observed for the <italic>LL</italic> participants having experienced multiple recent stressful events or severe lifetime traumas. Participants with the <italic>L</italic> allele also had higher evening cortisol stress response. Conversely, depression tended to be associated with a 42% higher basal morning cortisol in the <italic>SS</italic> participants specifically, but did not modify the association between stressful events and cortisol levels.</p></sec><sec><title>Conclusion</title><p>An adverse psychological environment is associated with basal cortisol levels and cortisol stress response, but this differs according to <italic>5-HTTLPR</italic> genotype.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anacker, C" uniqKey="Anacker C">C. Anacker</name></author><author><name sortKey="Zunszain, P A" uniqKey="Zunszain P">P.A. Zunszain</name></author><author><name sortKey="Carvalho, L A" uniqKey="Carvalho L">L.A. Carvalho</name></author><author><name sortKey="Pariante, C M" uniqKey="Pariante C">C.M. Pariante</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ancelin, M L" uniqKey="Ancelin M">M.L. Ancelin</name></author><author><name sortKey="Carriere, I" uniqKey="Carriere I">I. Carriere</name></author><author><name sortKey="Boulenger, J P" uniqKey="Boulenger J">J.P. Boulenger</name></author><author><name sortKey="Malafosse, A" uniqKey="Malafosse A">A. Malafosse</name></author><author><name sortKey="Stewart, R" uniqKey="Stewart R">R. Stewart</name></author><author><name sortKey="Cristol, J P" uniqKey="Cristol J">J.P. Cristol</name></author><author><name sortKey="Ritchie, K" uniqKey="Ritchie K">K. Ritchie</name></author><author><name sortKey="Chaudieu, I" uniqKey="Chaudieu I">I. Chaudieu</name></author><author><name sortKey="Dupuy, A M" uniqKey="Dupuy A">A.M. Dupuy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ancelin, M L" uniqKey="Ancelin M">M.L. Ancelin</name></author><author><name sortKey="Carriere, I" uniqKey="Carriere I">I. Carriere</name></author><author><name sortKey="Scali, J" uniqKey="Scali J">J. Scali</name></author><author><name sortKey="Ritchie, K" uniqKey="Ritchie K">K. Ritchie</name></author><author><name sortKey="Chaudieu, I" uniqKey="Chaudieu I">I. Chaudieu</name></author><author><name sortKey="Ryan, J" uniqKey="Ryan J">J. Ryan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ancelin, M L" uniqKey="Ancelin M">M.L. Ancelin</name></author><author><name sortKey="Ripoche, E" uniqKey="Ripoche E">E. Ripoche</name></author><author><name sortKey="Dupuy, A M" uniqKey="Dupuy A">A.M. Dupuy</name></author><author><name sortKey="Barberger Gateau, P" uniqKey="Barberger Gateau P">P. Barberger-Gateau</name></author><author><name sortKey="Auriacombe, S" uniqKey="Auriacombe S">S. Auriacombe</name></author><author><name sortKey="Rouaud, O" uniqKey="Rouaud O">O. Rouaud</name></author><author><name sortKey="Berr, C" uniqKey="Berr C">C. Berr</name></author><author><name sortKey="Carriere, I" uniqKey="Carriere I">I. Carriere</name></author><author><name sortKey="Ritchie, K" uniqKey="Ritchie K">K. Ritchie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrews, M H" uniqKey="Andrews M">M.H. Andrews</name></author><author><name sortKey="Matthews, S G" uniqKey="Matthews S">S.G. Matthews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beluche, I" uniqKey="Beluche I">I. Beluche</name></author><author><name sortKey="Chaudieu, I" uniqKey="Chaudieu I">I. Chaudieu</name></author><author><name sortKey="Norton, J" uniqKey="Norton J">J. Norton</name></author><author><name sortKey="Carriere, I" uniqKey="Carriere I">I. Carriere</name></author><author><name sortKey="Boulenger, J P" uniqKey="Boulenger J">J.P. Boulenger</name></author><author><name sortKey="Ritchie, K" uniqKey="Ritchie K">K. Ritchie</name></author><author><name sortKey="Ancelin, M L" uniqKey="Ancelin M">M.L. Ancelin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belvederi Murri, M" uniqKey="Belvederi Murri M">M. Belvederi Murri</name></author><author><name sortKey="Pariante, C" uniqKey="Pariante C">C. Pariante</name></author><author><name sortKey="Mondelli, V" uniqKey="Mondelli V">V. Mondelli</name></author><author><name sortKey="Masotti, M" uniqKey="Masotti M">M. Masotti</name></author><author><name sortKey="Atti, A R" uniqKey="Atti A">A.R. Atti</name></author><author><name sortKey="Mellacqua, Z" uniqKey="Mellacqua Z">Z. Mellacqua</name></author><author><name sortKey="Antonioli, M" uniqKey="Antonioli M">M. Antonioli</name></author><author><name sortKey="Ghio, L" uniqKey="Ghio L">L. Ghio</name></author><author><name sortKey="Menchetti, M" uniqKey="Menchetti M">M. Menchetti</name></author><author><name sortKey="Zanetidou, S" uniqKey="Zanetidou S">S. Zanetidou</name></author><author><name sortKey="Innamorati, M" uniqKey="Innamorati M">M. Innamorati</name></author><author><name sortKey="Amore, M" uniqKey="Amore M">M. Amore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bremmer, M A" uniqKey="Bremmer M">M.A. Bremmer</name></author><author><name sortKey="Deeg, D J" uniqKey="Deeg D">D.J. Deeg</name></author><author><name sortKey="Beekman, A T" uniqKey="Beekman A">A.T. Beekman</name></author><author><name sortKey="Penninx, B W" uniqKey="Penninx B">B.W. Penninx</name></author><author><name sortKey="Lips, P" uniqKey="Lips P">P. Lips</name></author><author><name sortKey="Hoogendijk, W J" uniqKey="Hoogendijk W">W.J. Hoogendijk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaudieu, I" uniqKey="Chaudieu I">I. Chaudieu</name></author><author><name sortKey="Beluche, I" uniqKey="Beluche I">I. Beluche</name></author><author><name sortKey="Norton, J" uniqKey="Norton J">J. Norton</name></author><author><name sortKey="Boulenger, J P" uniqKey="Boulenger J">J.P. Boulenger</name></author><author><name sortKey="Ritchie, K" uniqKey="Ritchie K">K. Ritchie</name></author><author><name sortKey="Ancelin, M L" uniqKey="Ancelin M">M.L. Ancelin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaudieu, I" uniqKey="Chaudieu I">I. Chaudieu</name></author><author><name sortKey="Norton, J" uniqKey="Norton J">J. Norton</name></author><author><name sortKey="Ritchie, K" uniqKey="Ritchie K">K. Ritchie</name></author><author><name sortKey="Birmes, P" uniqKey="Birmes P">P. Birmes</name></author><author><name sortKey="Vaiva, G" uniqKey="Vaiva G">G. Vaiva</name></author><author><name sortKey="Ancelin, M L" uniqKey="Ancelin M">M.L. Ancelin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiske, A" uniqKey="Fiske A">A. Fiske</name></author><author><name sortKey="Wetherell, J L" uniqKey="Wetherell J">J.L. Wetherell</name></author><author><name sortKey="Gatz, M" uniqKey="Gatz M">M. Gatz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Folstein, M F" uniqKey="Folstein M">M.F. Folstein</name></author><author><name sortKey="Folstein, S E" uniqKey="Folstein S">S.E. Folstein</name></author><author><name sortKey="Mchugh, P R" uniqKey="Mchugh P">P.R. McHugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Franz, C E" uniqKey="Franz C">C.E. Franz</name></author><author><name sortKey="York, T P" uniqKey="York T">T.P. York</name></author><author><name sortKey="Eaves, L J" uniqKey="Eaves L">L.J. Eaves</name></author><author><name sortKey="Mendoza, S P" uniqKey="Mendoza S">S.P. Mendoza</name></author><author><name sortKey="Hauger, R L" uniqKey="Hauger R">R.L. Hauger</name></author><author><name sortKey="Hellhammer, D H" uniqKey="Hellhammer D">D.H. Hellhammer</name></author><author><name sortKey="Jacobson, K C" uniqKey="Jacobson K">K.C. Jacobson</name></author><author><name sortKey="Levine, S" uniqKey="Levine S">S. Levine</name></author><author><name sortKey="Lupien, S J" uniqKey="Lupien S">S.J. Lupien</name></author><author><name sortKey="Lyons, M J" uniqKey="Lyons M">M.J. Lyons</name></author><author><name sortKey="Prom Wormley, E" uniqKey="Prom Wormley E">E. Prom-Wormley</name></author><author><name sortKey="Xian, H" uniqKey="Xian H">H. Xian</name></author><author><name sortKey="Kremen, W S" uniqKey="Kremen W">W.S. Kremen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuller, R W" uniqKey="Fuller R">R.W. Fuller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goodyer, I M" uniqKey="Goodyer I">I.M. Goodyer</name></author><author><name sortKey="Bacon, A" uniqKey="Bacon A">A. Bacon</name></author><author><name sortKey="Ban, M" uniqKey="Ban M">M. Ban</name></author><author><name sortKey="Croudace, T" uniqKey="Croudace T">T. Croudace</name></author><author><name sortKey="Herbert, J" uniqKey="Herbert J">J. Herbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grabe, H J" uniqKey="Grabe H">H.J. Grabe</name></author><author><name sortKey="Schwahn, C" uniqKey="Schwahn C">C. Schwahn</name></author><author><name sortKey="Appel, K" uniqKey="Appel K">K. Appel</name></author><author><name sortKey="Mahler, J" uniqKey="Mahler J">J. Mahler</name></author><author><name sortKey="Schulz, A" uniqKey="Schulz A">A. Schulz</name></author><author><name sortKey="Spitzer, C" uniqKey="Spitzer C">C. Spitzer</name></author><author><name sortKey="Barnow, S" uniqKey="Barnow S">S. Barnow</name></author><author><name sortKey="John, U" uniqKey="John U">U. John</name></author><author><name sortKey="Freyberger, H J" uniqKey="Freyberger H">H.J. Freyberger</name></author><author><name sortKey="Rosskopf, D" uniqKey="Rosskopf D">D. Rosskopf</name></author><author><name sortKey="Volzke, H" uniqKey="Volzke H">H. Volzke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grabe, H J" uniqKey="Grabe H">H.J. Grabe</name></author><author><name sortKey="Spitzer, C" uniqKey="Spitzer C">C. Spitzer</name></author><author><name sortKey="Schwahn, C" uniqKey="Schwahn C">C. Schwahn</name></author><author><name sortKey="Marcinek, A" uniqKey="Marcinek A">A. Marcinek</name></author><author><name sortKey="Frahnow, A" uniqKey="Frahnow A">A. Frahnow</name></author><author><name sortKey="Barnow, S" uniqKey="Barnow S">S. Barnow</name></author><author><name sortKey="Lucht, M" uniqKey="Lucht M">M. Lucht</name></author><author><name sortKey="Freyberger, H J" uniqKey="Freyberger H">H.J. Freyberger</name></author><author><name sortKey="John, U" uniqKey="John U">U. John</name></author><author><name sortKey="Wallaschofski, H" uniqKey="Wallaschofski H">H. Wallaschofski</name></author><author><name sortKey="Volzke, H" uniqKey="Volzke H">H. Volzke</name></author><author><name sortKey="Rosskopf, D" uniqKey="Rosskopf D">D. Rosskopf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harwood, R H" uniqKey="Harwood R">R.H. Harwood</name></author><author><name sortKey="Prince, M J" uniqKey="Prince M">M.J. Prince</name></author><author><name sortKey="Mann, A H" uniqKey="Mann A">A.H. Mann</name></author><author><name sortKey="Ebrahim, S" uniqKey="Ebrahim S">S. Ebrahim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hellhammer, D H" uniqKey="Hellhammer D">D.H. Hellhammer</name></author><author><name sortKey="Kirschbaum, C" uniqKey="Kirschbaum C">C. Kirschbaum</name></author><author><name sortKey="Belkien, L" uniqKey="Belkien L">L. Belkien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ice, G H" uniqKey="Ice G">G.H. Ice</name></author><author><name sortKey="Katz Stein, A" uniqKey="Katz Stein A">A. Katz-Stein</name></author><author><name sortKey="Himes, J" uniqKey="Himes J">J. Himes</name></author><author><name sortKey="Kane, R L" uniqKey="Kane R">R.L. Kane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Incollingo Rodriguez, A C" uniqKey="Incollingo Rodriguez A">A.C. Incollingo Rodriguez</name></author><author><name sortKey="Epel, E S" uniqKey="Epel E">E.S. Epel</name></author><author><name sortKey="White, M L" uniqKey="White M">M.L. White</name></author><author><name sortKey="Standen, E C" uniqKey="Standen E">E.C. Standen</name></author><author><name sortKey="Seckl, J R" uniqKey="Seckl J">J.R. Seckl</name></author><author><name sortKey="Tomiyama, A J" uniqKey="Tomiyama A">A.J. Tomiyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobs, N" uniqKey="Jacobs N">N. Jacobs</name></author><author><name sortKey="Nicolson, N A" uniqKey="Nicolson N">N.A. Nicolson</name></author><author><name sortKey="Derom, C" uniqKey="Derom C">C. Derom</name></author><author><name sortKey="Delespaul, P" uniqKey="Delespaul P">P. Delespaul</name></author><author><name sortKey="Van Os, J" uniqKey="Van Os J">J. van Os</name></author><author><name sortKey="Myin Germeys, I" uniqKey="Myin Germeys I">I. Myin-Germeys</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kraemer, H C" uniqKey="Kraemer H">H.C. Kraemer</name></author><author><name sortKey="Giese Davis, J" uniqKey="Giese Davis J">J. Giese-Davis</name></author><author><name sortKey="Yutsis, M" uniqKey="Yutsis M">M. Yutsis</name></author><author><name sortKey="O Hara, R" uniqKey="O Hara R">R. O'Hara</name></author><author><name sortKey="Neri, E" uniqKey="Neri E">E. Neri</name></author><author><name sortKey="Gallagher Thompson, D" uniqKey="Gallagher Thompson D">D. Gallagher-Thompson</name></author><author><name sortKey="Taylor, C B" uniqKey="Taylor C">C.B. Taylor</name></author><author><name sortKey="Spiegel, D" uniqKey="Spiegel D">D. Spiegel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kudielka, B M" uniqKey="Kudielka B">B.M. Kudielka</name></author><author><name sortKey="Gierens, A" uniqKey="Gierens A">A. Gierens</name></author><author><name sortKey="Hellhammer, D H" uniqKey="Hellhammer D">D.H. Hellhammer</name></author><author><name sortKey="Wust, S" uniqKey="Wust S">S. Wust</name></author><author><name sortKey="Schlotz, W" uniqKey="Schlotz W">W. Schlotz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lecrubier, Y" uniqKey="Lecrubier Y">Y. Lecrubier</name></author><author><name sortKey="Sheehan, D" uniqKey="Sheehan D">D. Sheehan</name></author><author><name sortKey="Weiller, E" uniqKey="Weiller E">E. Weiller</name></author><author><name sortKey="Amorim, P" uniqKey="Amorim P">P. Amorim</name></author><author><name sortKey="Bonora, I" uniqKey="Bonora I">I. Bonora</name></author><author><name sortKey="Harnett Sheehan, K" uniqKey="Harnett Sheehan K">K. Harnett Sheehan</name></author><author><name sortKey="Janavs, J" uniqKey="Janavs J">J. Janavs</name></author><author><name sortKey="Dunbar, G" uniqKey="Dunbar G">G. Dunbar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q. Li</name></author><author><name sortKey="Wichems, C" uniqKey="Wichems C">C. Wichems</name></author><author><name sortKey="Heils, A" uniqKey="Heils A">A. Heils</name></author><author><name sortKey="Van De Kar, L D" uniqKey="Van De Kar L">L.D. Van De Kar</name></author><author><name sortKey="Lesch, K P" uniqKey="Lesch K">K.P. Lesch</name></author><author><name sortKey="Murphy, D L" uniqKey="Murphy D">D.L. Murphy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lupien, S J" uniqKey="Lupien S">S.J. Lupien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lupien, S J" uniqKey="Lupien S">S.J. Lupien</name></author><author><name sortKey="Mcewen, B S" uniqKey="Mcewen B">B.S. McEwen</name></author><author><name sortKey="Gunnar, M R" uniqKey="Gunnar M">M.R. Gunnar</name></author><author><name sortKey="Heim, C" uniqKey="Heim C">C. Heim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, G E" uniqKey="Miller G">G.E. Miller</name></author><author><name sortKey="Chen, E" uniqKey="Chen E">E. Chen</name></author><author><name sortKey="Zhou, E S" uniqKey="Zhou E">E.S. Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, R" uniqKey="Miller R">R. Miller</name></author><author><name sortKey="Wankerl, M" uniqKey="Wankerl M">M. Wankerl</name></author><author><name sortKey="Stalder, T" uniqKey="Stalder T">T. Stalder</name></author><author><name sortKey="Kirschbaum, C" uniqKey="Kirschbaum C">C. Kirschbaum</name></author><author><name sortKey="Alexander, N" uniqKey="Alexander N">N. Alexander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morris, M C" uniqKey="Morris M">M.C. Morris</name></author><author><name sortKey="Compas, B E" uniqKey="Compas B">B.E. Compas</name></author><author><name sortKey="Garber, J" uniqKey="Garber J">J. Garber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mueller, A" uniqKey="Mueller A">A. Mueller</name></author><author><name sortKey="Armbruster, D" uniqKey="Armbruster D">D. Armbruster</name></author><author><name sortKey="Moser, D A" uniqKey="Moser D">D.A. Moser</name></author><author><name sortKey="Canli, T" uniqKey="Canli T">T. Canli</name></author><author><name sortKey="Lesch, K P" uniqKey="Lesch K">K.P. Lesch</name></author><author><name sortKey="Brocke, B" uniqKey="Brocke B">B. Brocke</name></author><author><name sortKey="Kirschbaum, C" uniqKey="Kirschbaum C">C. Kirschbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navarro Mateu, F" uniqKey="Navarro Mateu F">F. Navarro-Mateu</name></author><author><name sortKey="Escamez, T" uniqKey="Escamez T">T. Escamez</name></author><author><name sortKey="Koenen, K C" uniqKey="Koenen K">K.C. Koenen</name></author><author><name sortKey="Alonso, J" uniqKey="Alonso J">J. Alonso</name></author><author><name sortKey="Sanchez Meca, J" uniqKey="Sanchez Meca J">J. Sanchez-Meca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Otte, C" uniqKey="Otte C">C. Otte</name></author><author><name sortKey="Hart, S" uniqKey="Hart S">S. Hart</name></author><author><name sortKey="Neylan, T C" uniqKey="Neylan T">T.C. Neylan</name></author><author><name sortKey="Marmar, C R" uniqKey="Marmar C">C.R. Marmar</name></author><author><name sortKey="Yaffe, K" uniqKey="Yaffe K">K. Yaffe</name></author><author><name sortKey="Mohr, D C" uniqKey="Mohr D">D.C. Mohr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Porter, R J" uniqKey="Porter R">R.J. Porter</name></author><author><name sortKey="Gallagher, P" uniqKey="Gallagher P">P. Gallagher</name></author><author><name sortKey="Watson, S" uniqKey="Watson S">S. Watson</name></author><author><name sortKey="Young, A H" uniqKey="Young A">A.H. Young</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radloff, L" uniqKey="Radloff L">L. Radloff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ritchie, K" uniqKey="Ritchie K">K. Ritchie</name></author><author><name sortKey="Artero, S" uniqKey="Artero S">S. Artero</name></author><author><name sortKey="Beluche, I" uniqKey="Beluche I">I. Beluche</name></author><author><name sortKey="Ancelin, M L" uniqKey="Ancelin M">M.L. Ancelin</name></author><author><name sortKey="Mann, A" uniqKey="Mann A">A. Mann</name></author><author><name sortKey="Dupuy, A M" uniqKey="Dupuy A">A.M. Dupuy</name></author><author><name sortKey="Malafosse, A" uniqKey="Malafosse A">A. Malafosse</name></author><author><name sortKey="Boulenger, J P" uniqKey="Boulenger J">J.P. Boulenger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ritchie, K" uniqKey="Ritchie K">K. Ritchie</name></author><author><name sortKey="Jaussent, I" uniqKey="Jaussent I">I. Jaussent</name></author><author><name sortKey="Stewart, R" uniqKey="Stewart R">R. Stewart</name></author><author><name sortKey="Dupuy, A M" uniqKey="Dupuy A">A.M. Dupuy</name></author><author><name sortKey="Courtet, P" uniqKey="Courtet P">P. Courtet</name></author><author><name sortKey="Ancelin, M L" uniqKey="Ancelin M">M.L. Ancelin</name></author><author><name sortKey="Malafosse, A" uniqKey="Malafosse A">A. Malafosse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ritchie, K" uniqKey="Ritchie K">K. Ritchie</name></author><author><name sortKey="Norton, J" uniqKey="Norton J">J. Norton</name></author><author><name sortKey="Mann, A H" uniqKey="Mann A">A.H. Mann</name></author><author><name sortKey="Carriere, I" uniqKey="Carriere I">I. Carriere</name></author><author><name sortKey="Ancelin, M L" uniqKey="Ancelin M">M.L. Ancelin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharpley, C F" uniqKey="Sharpley C">C.F. Sharpley</name></author><author><name sortKey="Palanisamy, S K" uniqKey="Palanisamy S">S.K. Palanisamy</name></author><author><name sortKey="Glyde, N S" uniqKey="Glyde N">N.S. Glyde</name></author><author><name sortKey="Dillingham, P W" uniqKey="Dillingham P">P.W. Dillingham</name></author><author><name sortKey="Agnew, L L" uniqKey="Agnew L">L.L. Agnew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheehan, D V" uniqKey="Sheehan D">D.V. Sheehan</name></author><author><name sortKey="Lecrubier, Y" uniqKey="Lecrubier Y">Y. Lecrubier</name></author><author><name sortKey="Sheehan, K H" uniqKey="Sheehan K">K.H. Sheehan</name></author><author><name sortKey="Amorim, P" uniqKey="Amorim P">P. Amorim</name></author><author><name sortKey="Janavs, J" uniqKey="Janavs J">J. Janavs</name></author><author><name sortKey="Weiller, E" uniqKey="Weiller E">E. Weiller</name></author><author><name sortKey="Hergueta, T" uniqKey="Hergueta T">T. Hergueta</name></author><author><name sortKey="Baker, R" uniqKey="Baker R">R. Baker</name></author><author><name sortKey="Dunbar, G C" uniqKey="Dunbar G">G.C. Dunbar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stetler, C" uniqKey="Stetler C">C. Stetler</name></author><author><name sortKey="Miller, G E" uniqKey="Miller G">G.E. Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uher, R" uniqKey="Uher R">R. Uher</name></author><author><name sortKey="Mcguffin, P" uniqKey="Mcguffin P">P. McGuffin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vazquez, D M" uniqKey="Vazquez D">D.M. Vazquez</name></author><author><name sortKey="Neal, C R" uniqKey="Neal C">C.R. Neal</name></author><author><name sortKey="Patel, P D" uniqKey="Patel P">P.D. Patel</name></author><author><name sortKey="Kaciroti, N" uniqKey="Kaciroti N">N. Kaciroti</name></author><author><name sortKey="Lopez, J F" uniqKey="Lopez J">J.F. Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vinberg, M" uniqKey="Vinberg M">M. Vinberg</name></author><author><name sortKey="Mellerup, E" uniqKey="Mellerup E">E. Mellerup</name></author><author><name sortKey="Andersen, P K" uniqKey="Andersen P">P.K. Andersen</name></author><author><name sortKey="Bennike, B" uniqKey="Bennike B">B. Bennike</name></author><author><name sortKey="Kessing, L V" uniqKey="Kessing L">L.V. Kessing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watson, C G" uniqKey="Watson C">C.G. Watson</name></author><author><name sortKey="Juba, M P" uniqKey="Juba M">M.P. Juba</name></author><author><name sortKey="Manifold, V" uniqKey="Manifold V">V. Manifold</name></author><author><name sortKey="Kucala, T" uniqKey="Kucala T">T. Kucala</name></author><author><name sortKey="Anderson, P E" uniqKey="Anderson P">P.E. Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willner, C J" uniqKey="Willner C">C.J. Willner</name></author><author><name sortKey="Morris, P A" uniqKey="Morris P">P.A. Morris</name></author><author><name sortKey="Mccoy, D C" uniqKey="Mccoy D">D.C. McCoy</name></author><author><name sortKey="Adam, E K" uniqKey="Adam E">E.K. Adam</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Victoria (État)</li><li>Écosse</li></region><settlement><li>Melbourne</li><li>Montpellier</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Melbourne</li></orgName></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name></region><name sortKey="Ancelin, Marie Laure" sort="Ancelin, Marie Laure" uniqKey="Ancelin M" first="Marie-Laure" last="Ancelin">Marie-Laure Ancelin</name><name sortKey="Chaudieu, Isabelle" sort="Chaudieu, Isabelle" uniqKey="Chaudieu I" first="Isabelle" last="Chaudieu">Isabelle Chaudieu</name><name sortKey="Chaudieu, Isabelle" sort="Chaudieu, Isabelle" uniqKey="Chaudieu I" first="Isabelle" last="Chaudieu">Isabelle Chaudieu</name><name sortKey="Dupuy, Anne Marie" sort="Dupuy, Anne Marie" uniqKey="Dupuy A" first="Anne-Marie" last="Dupuy">Anne-Marie Dupuy</name><name sortKey="Dupuy, Anne Marie" sort="Dupuy, Anne Marie" uniqKey="Dupuy A" first="Anne-Marie" last="Dupuy">Anne-Marie Dupuy</name><name sortKey="Dupuy, Anne Marie" sort="Dupuy, Anne Marie" uniqKey="Dupuy A" first="Anne-Marie" last="Dupuy">Anne-Marie Dupuy</name><name sortKey="Norton, Joanna" sort="Norton, Joanna" uniqKey="Norton J" first="Joanna" last="Norton">Joanna Norton</name><name sortKey="Norton, Joanna" sort="Norton, Joanna" uniqKey="Norton J" first="Joanna" last="Norton">Joanna Norton</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name><name sortKey="Scali, Jacqueline" sort="Scali, Jacqueline" uniqKey="Scali J" first="Jacqueline" last="Scali">Jacqueline Scali</name><name sortKey="Scali, Jacqueline" sort="Scali, Jacqueline" uniqKey="Scali J" first="Jacqueline" last="Scali">Jacqueline Scali</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name></region><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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